A critical rate-limiting
step in the drug discovery process is
the availability of high-quality compound
libraries that have been designed for
screening specifically against important
target classes and for subsequent rapid
lead optimization. Our scientists have
created Lead Generation Libraries, comprising
diverse collections of chemical compounds
designed for disease-related families
of targets. We invest significant effort
in the process design and synthesis of
each library to ensure that the compounds
incorporate drug-like building blocks,
are highly pure and can be readily optimized.
We then screen these compound libraries
against important targets to identify
potential lead compounds. Compounds that
warrant further testing and refinement
as potential drug candidates are called
leads. We believe this strategy allows
us to increase the probability of finding
a high-quality lead for a given target.
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