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| Our experienced biology
teams are creating a better understanding
of how small molecule drugs interact with
targets. These teams clone, express and purify
related families of protein targets across
multiple therapeutic areas to gain insights
into their function. X-ray crystallography
and computational modeling are used to define
the three-dimensional structures of these
proteins. Utilizing this structural information,
chemists can design and synthesize new analogs
of lead compounds that are likely to have
a better fit with the target protein and improved
potency. |
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